Role of fenofibrate in multiple sclerosis.
Ahmad A AbulabanHayder M Al-KuraishyAli I Al-GareebEngy ElekhnawyAsma AlanaziAthanasios AlexiouMarios PapadakisGaber El-Saber BatihaPublished in: European journal of medical research (2024)
Multiple sclerosis (MS) is the most frequent inflammatory and demyelinating disease of the central nervous system (CNS). The underlying pathophysiology of MS is the destruction of myelin sheath by immune cells. The formation of myelin plaques, inflammation, and injury of neuronal myelin sheath characterizes its neuropathology. MS plaques are multiple focal regions of demyelination disseminated in the brain's white matter, spinal cords, deep grey matter, and cerebral cortex. Fenofibrate is a peroxisome proliferative activated receptor alpha (PPAR-α) that attenuates the inflammatory reactions in MS. Fenofibrate inhibits differentiation of Th17 by inhibiting the expression of pro-inflammatory signaling. According to these findings, this review intended to illuminate the mechanistic immunoinflammatory role of fenofibrate in mitigating MS neuropathology. In conclusion, fenofibrate can attenuate MS neuropathology by modulating different pathways, including oxidative stress, autophagy, mitochondrial dysfunction, inflammatory-signaling pathways, and neuroinflammation.
Keyphrases
- multiple sclerosis
- white matter
- oxidative stress
- mass spectrometry
- signaling pathway
- ms ms
- spinal cord
- traumatic brain injury
- cerebral ischemia
- diabetic rats
- insulin resistance
- subarachnoid hemorrhage
- ischemia reperfusion injury
- type diabetes
- spinal cord injury
- induced apoptosis
- binding protein
- metabolic syndrome
- epithelial mesenchymal transition
- pi k akt
- brain injury
- functional connectivity
- cell proliferation
- fatty acid
- cerebral blood flow