Primary Extra-Nodal DLBCL of Glands: Our Experiences outside Guidelines of Treatment.
Antonello SicaMario SantagataCaterina SagnelliPiero RambaldiRenato FrancoMassimiliano CretaPaola VitielloStefano CaccavaleVincenzo TammaroEvangelista SagnelliAndrea RonchiPublished in: Healthcare (Basel, Switzerland) (2021)
Lymphomas usually involve lymph nodes and other lymphoid tissues, but sometimes occur in non-lymphoid organs, called extra-nodal sites. Primary diffuse extra-lymph node large B-cell lymphoma (DLBCL) of the thyroid and parotid gland have been observed rarely. According to the most accredited guidelines, primary extra-nodal DLBCL of the parotid and thyroid glands should be treated with three cycles of R-CHOP followed by radiotherapy of the involved site (ISRT). Surgery alone is not enough to treat DLBCL. We describe two unusual cases of primary extra-nodal DLBCL in elderly patients treated exclusively with surgical resection, given the inability to apply chemotherapy. Both patients achieved clinical recovery, which was maintained after a follow-up of more than 18 months, despite not having performed the indicated chemotherapy protocol. The two cases presented here, and a few others reported in the literature, should be considered exceptions to the rule, and do not allow the conclusion that surgery alone might be sufficient for complete remission.
Keyphrases
- lymph node
- diffuse large b cell lymphoma
- neoadjuvant chemotherapy
- locally advanced
- minimally invasive
- sentinel lymph node
- newly diagnosed
- coronary artery bypass
- end stage renal disease
- ejection fraction
- systematic review
- early stage
- randomized controlled trial
- mental health
- clinical practice
- low grade
- middle aged
- acute coronary syndrome
- squamous cell carcinoma
- atrial fibrillation
- high grade
- percutaneous coronary intervention
- prognostic factors
- combination therapy
- rectal cancer