Immunosuppression in stem cell clinical trials of neural and retinal cell types: A systematic review.
Shravan GowrishankarMatthew E SmithNathan J CreberSayed Jameel MuzaffarDaniele BorsettoPublished in: PloS one (2024)
A short-term course of systemic immunosuppression seemed efficacious for most included studies, with some showing grafted cells viable months to years after immunosuppression had stopped. Longer-term follow-up is required to see if this remains the case. Side effects related to immunosuppression were uncommon.
Keyphrases
- stem cells
- clinical trial
- induced apoptosis
- cell therapy
- single cell
- preterm infants
- cell cycle arrest
- optical coherence tomography
- diabetic retinopathy
- randomized controlled trial
- oxidative stress
- cell death
- mesenchymal stem cells
- endoplasmic reticulum stress
- bone marrow
- cell proliferation
- gestational age
- open label
- pi k akt
- drug induced