Optimization of antimicrobials in the treatment of cystic fibrosis pulmonary exacerbations: II. Therapies for allergic bronchopulmonary aspergillosis.
Quovadis J EppsKevin L EppsJeffrey T ZobellDavid C YoungPublished in: Pediatric pulmonology (2020)
This review is the second article in the State-of-the-Art series and aims to evaluate medications used in the treatment of allergic bronchopulmonary aspergillosis (ABPA) in pediatric and adult patients with cystic fibrosis (CF). ABPA is one of several organisms that are found in the airways of CF patients. This review provides an evidence-based summary of pharmacokinetic (PK)/pharmacodynamic (PD), tolerability, and efficacy studies of medications including corticosteroids, amphotericin B, azole antifungals (isavuconazole, itraconazole, posaconazole, and voriconazole), and a monoclonal antibody omalizumab in the treatment of ABPA and identifies areas where further study is warranted.
Keyphrases
- cystic fibrosis
- pseudomonas aeruginosa
- monoclonal antibody
- end stage renal disease
- clinical trial
- randomized controlled trial
- chronic obstructive pulmonary disease
- newly diagnosed
- chronic kidney disease
- combination therapy
- pulmonary hypertension
- ejection fraction
- open label
- gene expression
- genome wide
- air pollution
- study protocol
- case control