Closed and High-Quality Bacterial Genome Sequences of the Oligo-Mouse-Microbiota Community.

Quentin Lamy-Besnier Romain Koszul Laurent Debarbieux Martial Marbouty

Published in: Microbiology resource announcements (2021)

The Oligo-Mouse-Microbiota (OMM12) gnotobiotic murine model is an increasingly popular model in microbiota studies. However, following Illumina and PacBio sequencing, the genomes of the 12 strains could not be closed. Here, we used genomic chromosome conformation capture (Hi-C) data to reorganize, close, and improve the quality of these 12 genomes.

Keyphrases

copy number
escherichia coli
healthcare
single cell
big data
machine learning
molecular dynamics simulations
gene expression
genome wide
dna methylation
quality improvement