Clozapine As Transformative Treatment In Bipolar Patients.

Published in: Neuropsychiatric disease and treatment (2019)

Clozapine is an atypical antipsychotic used in treatment-resistant bipolar disorder. There is evidence for its anti-suicidal, anti-aggressive properties and efficacy in substance use comorbidities. Despite guidelines, the drug is used in 1.5% of bipolar patients only. Considering its effectiveness in treatment-resistant cases as well as its epigenetic effects it may become transformative treatment in bipolar disorder impacting the clinical course and psychosocial burden of the disease.

Keyphrases

bipolar disorder
ejection fraction
major depressive disorder
newly diagnosed
randomized controlled trial
systematic review
prognostic factors
mental health
clinical practice
replacement therapy
drug induced