Blood-thirsty: S1PR5 and TRM.

Published in: The Journal of experimental medicine (2021)

In this elegant study, Evrard et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20210116) find that sphingosine 1-phosphate receptor 5 (S1PR5) powerfully impairs tissue-resident memory T cell (TRM) formation, and that tissue-derived TGF-β limits S1pr5 expression by infiltrating T cells.

Keyphrases

poor prognosis
transforming growth factor
binding protein
working memory
quality improvement
epithelial mesenchymal transition