Quantification of microbubble-induced sonothrombolysis in an ex vivo non-human primate model.

Monica T HindsAzzdine Y AmmiJennifer JohnsonSanjiv Kaul

Published in: Journal of thrombosis and haemostasis : JTH (2020)

rtPA + MB + US (0.25 and 1.05 MHz) resulted in inhibition of platelet accumulation on the thrombogenic device when moderately high PRAPAs (≥1.75 MPa) were used. These results taken in context with lytic effects of US on myocardial microthrombi and direct effect on myocardial blood flow and function provide direction for the use of therapeutic US in acute coronary syndromes.

Keyphrases

blood flow
acute coronary syndrome
endothelial cells
left ventricular
high glucose
diabetic rats
percutaneous coronary intervention
pluripotent stem cells
antiplatelet therapy
drug induced
coronary artery disease
heart failure