Gene and immunohistochemical expression of HIF-1α, GLUT-1, FASN, and adipophilin in carcinoma ex pleomorphic adenoma development.

João Figueira ScariniLarissa Fernandes RosaReydson Alcides de Lima SouzaErika Said Abu EgalAlfio José TincaniAntônio Santos MartinsLuiz Paulo Kowalski Edgard Graner Ricardo Della ColettaRoman CarlosRogério de Oliveira Gondak Oslei Paes de AlmeidaAlbina Messias de Almeida Milani AltemaniDébora Campanella BastosFernanda Viviane Mariano

Published in: Oral diseases (2020)

In summary, the data presented here suggest that neoplastic cells reprogram the expression of GLUT-1 and adipophilin to adapt to the tumor microenvironment and reinforce, through immunohistochemical results, a possible transcriptional and post-translational regulatory mechanisms that act on the expression of these genes.

Keyphrases

poor prognosis
genome wide
binding protein
induced apoptosis
endothelial cells
machine learning
copy number
electronic health record
cell proliferation
cell cycle arrest
signaling pathway
endoplasmic reticulum stress
heat shock
heat shock protein