PIGA Mutations and Glycosylphosphatidylinositol Anchor Dysregulation in Polyposis-Associated Duodenal Tumorigenesis.

Elena Meuser Kyle Chang Angharad Walters Joanna J Hurley Hannah D West Iain Perry Matthew Mort Laura Reyes-Uribe Rebekah Truscott Nicholas Jones Rachel Lawrence Gareth J S Jenkins Peter J Giles Sunil Dolwani Bilal Al-Sarireh Neil Hawkes Emma L Short Geraint T Williams Melissa W Taggart Kim Luetchford Patrick M Lynch Diantha Terlouw Maartje Nielsen Sarah-Jane Walton Andrew Latchford Susan K Clark Julian R Sampson Eduardo Vilar Laura E Thomas

Published in: Molecular cancer research : MCR (2024)

PIGA somatic mutation in duodenal tumors from patients with FAP and MAP and loss of membrane GPI-anchors may present new opportunities for understanding and intervention in duodenal tumorigenesis.

Keyphrases

randomized controlled trial
copy number
gene expression
high density