The effect of two selective A1 -receptor agonists and the bitopic ligand VCP746 on heart rate and regional vascular conductance in conscious rats.
Samantha L CooperJulie MarchAndrea R SabbatiniStephen J HillManuela JörgPeter J ScammellsJeanette WoolardPublished in: British journal of pharmacology (2020)
These results suggest VCP746 mediates its cardiovascular effects via activation of A2 rather than A1 adenosine receptors. This has implications for the design of future bitopic ligands that incorporate A1 allosteric ligand moieties.