Genetic factors affecting survival in Japanese patients with sporadic amyotrophic lateral sclerosis: a genome-wide association study and verification in iPSC-derived motor neurons from patients.
Ryoichi NakamuraGenki TohnaiMasahiro NakatochiNaoki AtsutaHirohisa WatanabeDaisuke ItoMasahisa KatsunoAkihiro HirakawaYuishin IzumiMitsuya MoritaTakehisa HirayamaOsamu KanoKazuaki KanaiNobutaka HattoriAkira TaniguchiNaoki SuzukiMasashi AokiIkuko IwataIchiro YabeKazumoto ShibuyaSatoshi KuwabaraMasaya OdaRina HashimotoIkuko AibaTomohiko IshiharaOsamu OnoderaToru YamashitaKoji AbeKouichi MizoguchiToshio ShimizuYoshio IkedaTakanori YokotaKazuko HasegawaFumiaki TanakaKenji NakashimaRyuji KajiJun-Ichi NiwaManabu DoyuChikashi TeraoShiro IkegawaKoki FujimoriShiho NakamuraFumiko OzawaSatoru MorimotoKazunari OnoderaTakuji ItoYohei OkadaHideyuki OkanoSatomi Mitsuhashinull nullPublished in: Journal of neurology, neurosurgery, and psychiatry (2023)
and the viability of iPSC-MNs from patients. The iPSC-MN model reflects the association between patient prognosis and genotype and can contribute to target screening and validation for therapeutic intervention.