Prostate-Specific Membrane Antigen-Targeting Alpha Emitter via Antibody Delivery for Metastatic Castration-Resistant Prostate Cancer: A Phase I Dose-Escalation Study of 225 Ac-J591.
Scott T TagawaCharlene ThomasA Oliver SartorMichael SunJudith Stangl-KremserMahelia BissassarShankar VallabhajosulaSandra Huicochea CastellanosJones T NauseefCora N SternbergAna MolinaKarla V BallmanDavid M NanusJoseph R OsborneNeil H BanderPublished in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2023)
Ac-J591 in 32 patients with pretreated progressive mCRPC demonstrated safety and preliminary efficacy signals. Further investigation is underway.