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An updated molecular diagnostic for surveillance of tetM in Neisseria gonorrhoeae .

Samantha G PalaceJordan A ReyesEric Neubauer VickersAishani V AatreshWei ShenZamin IqbalYonatan Hagai Grad
Published in: medRxiv : the preprint server for health sciences (2024)
Doxycycline post-exposure prophylaxis (doxy-PEP) for sexually transmitted bacterial infections reduces the risk of syphilis and chlamydia, but effectiveness against gonorrhea is variable, likely attributable to varying resistance rates. As doxy-PEP is incorporated into clinical practice, an urgent unanswered question is whether increased doxycycline use will drive tetracycline-class resistance in Neisseria gonorrhoeae . Here, we report an updated RT-PCR molecular diagnostic to detect the tetM gene that confers high-level tetracycline resistance in N. gonorrhoeae .
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