Phase II proof-of-concept study of atorvastatin in castration-resistant prostate cancer.
Linda K RushworthCarolyn LoveridgeMark J SaljiMartin MacLeodErnest MuiDavid SumptonMatthew NeilsonAnn HedleyLaura AlexanderElaine McCartneyRachana PatelJan WallaceChristian DellesRobert J JonesHing Y LeungPublished in: BJU international (2022)
Data from the SPECTRE study provide the first evidence of statin-mediated effects on CRPC and early sign of disease stabilization. Our data also highlight the possibility of altered tryptophan metabolism being associated with tumour response.