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David Sumpton

ORCID

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 25

Top Venues

Nature communications

Cancer research

Cell death & disease

Communications chemistry

Beatson Institute for Cancer Research

University of York (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Beatson Institute for Cancer Research Feb 1o 2020

United Kingdom

Head of Metabolomics :: Metabolomics Facility

Education History

University of York

United Kingdom

PHD :: Chemistry

Publications

Kevin M Rattigan, Zuzana Brabcova, Daniele Sarnello, Martha M Zarou, Kiron Roy, Ryan Kwan, Lucie de Beauchamp, Amy Dawson, Angela Ianniciello, Ahmed Khalaf, Eric R Kalkman, Mary T Scott, Karen M Dunn, David Sumpton, Alison M Michie, Mhairi Copland, Saverio Tardito, Eyal Gottlieb, G Vignir Helgason
Pyruvate anaplerosis is a targetable vulnerability in persistent leukaemic stem cells. Nature communications 14 (1) (2023)
Kevin M Rattigan, Martha M Zarou, Zuzana Brabcova, Bodhayan Prasad, Désirée Zerbst, Daniele Sarnello, Eric R Kalkman, Angela Ianniciello, Mary T Scott, Karen Dunn, Engy Shokry, David Sumpton, Mhairi Copland, Saverio Tardito, Johan Vande Voorde, Francis Jay Mussai, Paul Cheng, G Vignir Helgason
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells. EMBO reports (2023)
Luisa Ricci, Federico Uchenna Stanley, Tanja Eberhart, Francesco Mainini, David Sumpton, Simone Cardaci
Pyruvate transamination and NAD biosynthesis enable proliferation of succinate dehydrogenase-deficient cells by supporting aerobic glycolysis. Cell death & disease 14 (7) (2023)
Johan Vande Voorde, Rory T Steven, Arafath K Najumudeen, Catriona A Ford, Alex Dexter, Ariadna Gonzalez-Fernandez, Chelsea J Nikula, Yuchen Xiang, Lauren Ford, Stefania Maneta Stavrakaki, Kathryn Gilroy, Lucas B Zeiger, Kathryn Pennel, Phimmada Hatthakarnkul, Efstathios A Elia, Ammar Nasif, Teresa Murta, Eftychios Manoli, Sam Mason, Michael Gillespie, Tamsin R M Lannagan, Nikola Vlahov, Rachel A Ridgway, Colin Nixon, Alexander Raven, Megan Mills, Dimitris Athineos, Georgios Kanellos, Craig Nourse, David M Gay, Mark Hughes, Amy Burton, Bin Yan, Katherine Sellers, Vincen Wu, Kobe De Ridder, Engy Shokry, Alejandro Huerta Uribe, William Clark, Graeme Clark, Kristina Kirschner, Bernard Thienpont, Vivian Sze Wing Li, Oliver D K Maddocks, Simon T Barry, Richard J A Goodwin, James Macalister Kinross, Joanne Edwards, Mariia O Yuneva, David Sumpton, Zoltán Takáts, Andrew D Campbell, Josephine Bunch, Owen James Sansom
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target. Nature metabolism (2023)
Linda K Rushworth, Carolyn Loveridge, Mark J Salji, Martin MacLeod, Ernest Mui, David Sumpton, Matthew Neilson, Ann Hedley, Laura Alexander, Elaine McCartney, Rachana Patel, Jan Wallace, Christian Delles, Robert J Jones, Hing Y Leung
Phase II proof-of-concept study of atorvastatin in castration-resistant prostate cancer. BJU international (2022)
Rachana Patel, Catriona A Ford, Lisa Rodgers, Linda K Rushworth, Janis Fleming, Ernest Mui, Tong Zhang, David G Watson, Victoria Lynch, Gillian Mackay, David Sumpton, Owen James Sansom, Johan Vande Voorde, Hing Y Leung
Cyclocreatine Suppresses Creatine Metabolism and Impairs Prostate Cancer Progression. Cancer research 82 (14) (2022)
Emily J Kay, Karla Paterson, Carla Riera-Domingo, David Sumpton, J Henry M Däbritz, Saverio Tardito, Claudia Boldrini, Juan Ramon Hernandez-Fernaud, Dimitris Athineos, Sandeep Dhayade, Ekaterina Stepanova, Enio Gjerga, Lisa J Neilson, Sergio Lilla, Ann Hedley, Grigorios Koulouras, Grace McGregor, Craig Jamieson, Radia Marie Johnson, Morag Park, Kristina Kirschner, Crispin Miller, Jurre J Kamphorst, Fabricio Loayza-Puch, Julio Saez-Rodriguez, Massimiliano Mazzone, Karen Blyth, Michele Zagnoni, Sara R Zanivan
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix. Nature metabolism 4 (6) (2022)
Victor H Villar, Maria Francesca Allega, Ruhi S Deshmukh, Tobias Ackermann, Mark A Nakasone, Johan Vande Voorde, Thomas M Drake, Janina Oetjen, Algernon Bloom, Colin Nixon, Miryam Müller, Stephanie May, Ee Hong Tan, Lars Vereecke, Maude Jans, Gillian Blancke, Daniel J Murphy, Danny T Huang, David Y Lewis, Thomas G Bird, Owen James Sansom, Karen Blyth, David Sumpton, Saverio Tardito
Hepatic glutamine synthetase controls N 5 -methylglutamine in homeostasis and cancer. Nature chemical biology (2022)
Arnaud Blomme, Coralie Peter, Ernest Mui, Giovanny Rodriguez Blanco, Ning An, Louise M Mason, Lauren E Jamieson, Grace H McGregor, Sergio Lilla, Chara Ntala, Rachana Patel, Marc Thiry, Sonia H Y Kung, Marine Leclercq, Catriona A Ford, Linda K Rushworth, David J McGarry, Susan Mason, Peter Repiscak, Colin Nixon, Mark J Salji, Elke Markert, Gillian M MacKay, Jurre J Kamphorst, Duncan Graham, Karen Faulds, Ladan Fazli, Martin E Gleave, Edward Avezov, Joanne Edwards, Huabing Yin, David Sumpton, Karen Blyth, Pierre Close, Daniel J Murphy, Sara R Zanivan, Hing Y Leung
THEM6-mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer. EMBO molecular medicine 14 (3) (2022)
Stefano Grosso, Alberto Marini, Katarina Gyuraszova, Johan Vande Voorde, Aristeidis Sfakianos, Gavin D Garland, Angela Rubio Tenor, Ryan Mordue, Tanya Chernova, Nobuhiro Morone, Marco Sereno, Claire Rachel Smith, Leah Officer, Pooyeh Farahmand, Claire Rooney, David Sumpton, Madhumita Das, Ana Teodosio, Catherine Ficken, Maria Guerra Martin, Ruth V Spriggs, Xiao-Ming Sun, Martin Bushell, Owen James Sansom, Daniel J Murphy, Marion MacFarlane, John P C Le Quesne, Anne E Willis
The pathogenesis of mesothelioma is driven by a dysregulated translatome. Nature communications 12 (1) (2021)
Arafath K Najumudeen, Fatih Ceteci, Sigrid K Fey, Gregory Hamm, Rory T Steven, Holly Hall, Chelsea J Nikula, Alex Dexter, Teresa Murta, Alan M Race, David Sumpton, Nikola Vlahov, David M Gay, John R P Knight, Rene Jackstadt, Joshua D G Leach, Rachel A Ridgway, Emma R Johnson, Colin Nixon, Ann Hedley, Kathryn Gilroy, William Clark, Sudhir B Malla, Philip D Dunne, Giovanny Rodriguez Blanco, Susan E Critchlow, Agata Mrowinska, Gaurav Malviya, Dmitry Solovyev, Gavin Brown, David Y Lewis, Gillian M Mackay, Douglas Strathdee, Saverio Tardito, Eyal Gottlieb, null null, Zoltan Takats, Simon T Barry, Richard J A Goodwin, Josephine Bunch, Martin Bushell, Andrew D Campbell, Owen James Sansom
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer. Nature genetics 53 (1) (2021)
Rafael S Martinez, Mark J Salji, Linda Rushworth, Chara Ntala, Giovanny Rodriguez Blanco, Ann Hedley, William Clark, Paul Peixoto, Eric Hervouet, Elodie Renaude, Sonia H Y Kung, Laura C A Galbraith, Colin Nixon, Sergio Lilla, Gillian M MacKay, Ladan Fazli, Luke Gaughan, David Sumpton, Martin E Gleave, Sara R Zanivan, Arnaud Blomme, Hing Y Leung
SLFN5 Regulates LAT1-Mediated mTOR Activation in Castration-Resistant Prostate Cancer. Cancer research 81 (13) (2021)
Syed Feroj Ahmed, Lori Buetow, Mads Gabrielsen, Sergio Lilla, Gary J Sibbet, David Sumpton, Sara Zanivan, Ann Hedley, William Clark, Danny T Huang
E3 ligase-inactivation rewires CBL interactome to elicit oncogenesis by hijacking RTK-CBL-CIN85 axis. Oncogene 40 (12) (2021)
Matthias Pietzke, Guillermo Burgos-Barragan, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Gillian M Mackay, Ketan J Patel, Alexei Vazquez
Amino acid dependent formaldehyde metabolism in mammals. Communications chemistry 3 (1) (2020)
Alba Roca-Portoles, Giovanny Rodriguez-Blanco, David Sumpton, Catherine Cloix, Margaret Mullin, Gillian M Mackay, Katelyn O'Neill, Leandro Lemgruber Soares, Xu Luo, Stephen W G Tait
Venetoclax causes metabolic reprogramming independent of BCL-2 inhibition. Cell death & disease 11 (8) (2020)
Simone Torretta, Alessandra Scagliola, Luisa Ricci, Francesco Mainini, Sabrina Di Marco, Ivan Cuccovillo, Anna Kajaste-Rudnitski, David Sumpton, Kevin M Ryan, Simone Cardaci
D-mannose suppresses macrophage IL-1β production. Nature communications 11 (1) (2020)
Sandeep Dhayade, Matthias Pietzke, Robert Wiesheu, Jacqueline Tait-Mulder, Dimitris Athineos, David Sumpton, Seth B Coffelt, Karen Blyth, Alexei Vazquez
Impact of Formate Supplementation on Body Weight and Plasma Amino Acids. Nutrients 12 (8) (2020)
Matthias Pietzke, Guillermo Burgos-Barragan, Niek Wit, Jacqueline Tait-Mulder, David Sumpton, Gillian M Mackay, Ketan J Patel, Alexei Vazquez
Amino acid dependent formaldehyde metabolism in mammals. Communications chemistry 3 (1) (2020)
Arnaud Blomme, Catriona A Ford, Ernest Mui, Rachana Patel, Chara Ntala, Lauren E Jamieson, Mélanie Planque, Grace H McGregor, Paul Peixoto, Eric Hervouet, Colin Nixon, Mark Salji, Luke Gaughan, Elke Markert, Peter Repiscak, David Sumpton, Giovanny Rodriguez Blanco, Sergio Lilla, Jurre J Kamphorst, Duncan Graham, Karen Faulds, Gillian M MacKay, Sarah-Maria Fendt, Sara R Zanivan, Hing Y Leung
2,4-dienoyl-CoA reductase regulates lipid homeostasis in treatment-resistant prostate cancer. Nature communications 11 (1) (2020)
Kristell Oizel, Jacqueline Tait-Mulder, Jorge Fernandez-de-Cossio-Diaz, Matthias Pietzke, Holly Brunton, Sergio Lilla, Sandeep Dhayade, Dimitris Athineos, Giovanny Rodriguez Blanco, David Sumpton, Gillian M Mackay, Karen Blyth, Sara R Zanivan, Johannes Meiser, Alexei Vazquez
Formate induces a metabolic switch in nucleotide and energy metabolism. Cell death & disease 11 (5) (2020)
Chatrin Chatrin, Mads Gabrielsen, Lori Buetow, Mark A Nakasone, Syed Feroj Ahmed, David Sumpton, Gary J Sibbet, Brian O Smith, Danny T Huang
Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases. Science advances 6 (38) (2020)
Grace H McGregor, Andrew D Campbell, Sigrid K Fey, Sergey Tumanov, David Sumpton, Giovanny Rodriguez Blanco, Gillian Mackay, Colin Nixon, Alexei Vazquez, Owen J Sansom, Jurre J Kamphorst
Targeting the Metabolic Response to Statin-Mediated Oxidative Stress Produces a Synergistic Antitumor Response. Cancer research 80 (2) (2019)
Johan Vande Voorde, Tobias Ackermann, Nadja Pfetzer, David Sumpton, Gillian Mackay, Gabriela Kalna, Colin Nixon, Karen Blyth, Eyal Gottlieb, Saverio Tardito
Improving the metabolic fidelity of cancer models with a physiological cell culture medium. Science advances 5 (1) (2019)
David Novo, Nikki Heath, Louise Mitchell, Giuseppina Caligiuri, Amanda MacFarlane, Dide Reijmer, Laura Charlton, John Knight, Monika Calka, Ewan McGhee, Emmanuel Dornier, David Sumpton, Susan Mason, Arnaud Echard, Kerstin Klinkert, Judith Secklehner, Flore Kruiswijk, Karen Vousden, Iain R J Macpherson, Karen Blyth, Peter Bailey, Huabing Yin, Leo M Carlin, Jennifer Morton, Sara R Zanivan, Jim C Norman
Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels. Nature communications 9 (1) (2018)
Maria Dandoulaki, Eleni Petsalaki, David Sumpton, Sara R Zanivan, George Zachos
Src activation by Chk1 promotes actin patch formation and prevents chromatin bridge breakage in cytokinesis. The Journal of cell biology 217 (9) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

David Sumpton