Login / Signup

Hypoxic stress disrupts HGF/Met signaling in human trophoblasts: implications for the pathogenesis of preeclampsia.

Guanlin LiYongqing WangGuangming CaoYeling MaYu-Xia LiYangyu ZhaoXuan ShaoYan-Ling Wang
Published in: Journal of biomedical science (2022)
These findings reveal that prolonged hypoxic stress induces the augmentation of endocytosis and repression of ubiquitin-mediated Met degradation, which leads to the impaired regulation of trophoblast invasion by HGF/Met signaling. These data provide novel evidence for elucidating the pathogenesis of preeclampsia, especially of the early-onset subtype.
Keyphrases