Morpho-functional analysis of patient-derived xenografts reveals differential impact of gastric cancer and chemotherapy on the tumor ecosystem, affecting immune check point, metabolism, and sarcopenia.

A VenkatasamyE GuerinW ReichardtV DevignotM P ChenardL MiguetB RomainA C JungI GrossC GaiddonGeorg Mellitzer

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2022)

Our PDX models are representative for the heterogeneity and complexity of human tumors, with differences in structure, histology, muscle atrophy, and the different biomarkers making them valuable for the analyses of the impact of platinum drugs or new therapies on the tumor and its microenvironment.

Keyphrases

skeletal muscle
endothelial cells
stem cells
induced pluripotent stem cells
locally advanced
cross sectional
squamous cell carcinoma
risk assessment
human health