Homologous Recombination Deficiency in Pancreatic Cancer: A Systematic Review and Prevalence Meta-Analysis.

Raffaella CasolinoSalvatore PaiellaDanila AzzolinaPhilip A BeerVincenzo CorboGiulia Lorenzoni Dario Gregori Talia GolanChiara BraconiFieke E M FroelingMichele MilellaAldo ScarpaAntonio PeaGiuseppe MalleoRoberto SalviaClaudio BassiDavid K Chang Andrew V Biankin

Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)

Surrogate readouts of HRD identify a greater proportion of patients with HRD than analyses limited to gene-level approaches. There is a clear need to harmonize HRD definitions and to validate the optimal biomarker for treatment selection. Universal HRD screening including integrated somatic and germline analysis should be offered to all patients with PDAC.

Keyphrases

dna repair
systematic review
dna damage
copy number
risk factors
meta analyses
genome wide
randomized controlled trial
gene expression
oxidative stress
combination therapy
transcription factor