Pulmonary emphysema and coronary artery calcifications at baseline LDCT and long-term mortality in smokers and former smokers of the ITALUNG screening trial.
Mario MascalchiChiara RomeiChiara MarziStefano DiciottiGiulia PicozziFrancesco PistelliMarco ZappaEugenio PaciFrancesca CarozziGiuseppe GoriniFabio FalaschiAnna Lisa DeliperiGianna CamiciottoliLaura CarrozziDonella PulitiPublished in: European radiology (2023)
• Densitometry allows quantification of pulmonary emphysematous changes in low-dose CT examinations for lung cancer screening. • Emphysematous lung density changes are an independent predictor of long-term overall and cardio-vascular disease mortality in smokers and former smokers undergoing screening. • Emphysematous changes quantification should be included in the post-test calculation of the individual mortality risk profile.
Keyphrases
- smoking cessation
- low dose
- coronary artery
- pulmonary hypertension
- cardiovascular events
- clinical trial
- study protocol
- randomized controlled trial
- type diabetes
- coronary artery disease
- magnetic resonance imaging
- magnetic resonance
- contrast enhanced
- positron emission tomography
- phase ii
- image quality
- cystic fibrosis
- open label
- pulmonary arterial hypertension