Construction of Fzd6 Q152E mice through CRISPR/Cas9 technology and their reproduction and identification.

Xiaoru YanJunting YangLanfei XiaoJiping GaoGuoqiang XuLiang WangYang QiGuohua Song

Published in: Molecular biology reports (2022)

Our study successfully established homozygous Fzd6 mutant mice model. The relationship between Fzd6-Wnt and depression was preliminarily clarified, which provides an ideal animal model for subsequent research on diseases induced by the Fzd6 mutation.

Keyphrases

crispr cas
high fat diet induced
wild type
genome editing
stem cells
depressive symptoms
cell proliferation
insulin resistance
physical activity
metabolic syndrome
bioinformatics analysis