Knockdown of trem2 promotes proinflammatory microglia and inhibits glioma progression via the JAK2/STAT3 and NF-κB pathways.

Yunji YanShengwei BaiHongxi HanJunqiang DaiLiang NiuHongyu WangQiang DongHang YinGuoqiang YuanHongyu Wang

Published in: Cell communication and signaling : CCS (2024)

Our findings revealed that trem2 in microglia plays a significant role in the TIME of gliomas. Knockdown of trem2 in microglia might help to improve the efficiency of inhibiting glioma growth and delaying tumor progression and provide new ideas for further treatment of glioma.

Keyphrases

inflammatory response
neuropathic pain
signaling pathway
lps induced
poor prognosis
single cell
pi k akt
spinal cord injury
toll like receptor
combination therapy
long non coding rna