Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation.

Volker Martin LauschkeSabine U VorrinkSabrina M L MoroFatemah RezayeeÅsa NordlingDelilah F G HendriksCatherine C BellRowena Sison-YoungB Kevin ParkChristopher E GoldringEwa C S EllisInger JohanssonSouren MkrtchianTommy B AnderssonMagnus Ingelman-Sundberg

Published in: Hepatology (Baltimore, Md.) (2016)

miRNAs are important drivers of hepatic dedifferentiation, and our results provide valuable information regarding the mechanisms behind liver regeneration and possibilities to inhibit dedifferentiation in vitro. (Hepatology 2016;64:1743-1756).

Keyphrases

stem cells
genome wide
liver injury
healthcare
health information
gene expression
dna methylation
drug induced