PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ in the joint microenvironment.
Yao YaoXiaoyu CaiMeng ZhangXiao ZhangFujia RenYan ZhengWeidong FeiMengdan ZhaoCaihong ZhengPublished in: Arthritis research & therapy (2022)
Together, this study reveals that PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ to form an immunological barrier (F4/80<sup>+</sup>PSTPIP2<sup>hi</sup> cell-enriched zone) for the joints. Thus, local modulation of PSTPIP2 expression in the joint microenvironment may be a potential strategy for controlling bone erosion in rheumatoid arthritis. PSTPIP2 regulates synovial macrophages polarization and dynamics via ERβ to form F4/80<sup>+</sup>PSTPIP2<sup>hi</sup> cellular barrier in joint microenvironment.