Acute basophilic leukemia associated with the t(16;21)(p11;q22)/FUS-ERG fusion gene.

Yusuke TodaYuya NagaiDaiki ShimomuraChiyuki KishimoriKatsuyo TsudaKatsuhiro FukutsukaMasahiko HayashidaHitoshi Ohno

Published in: Clinical case reports (2017)

We herein report a rare case of acute basophilic leukemia with t(16;21)(p11;q22) generating the FUS-ERG fusion gene. The basophilic nature of leukemia blasts was demonstrated by cytomorphology, toluidine blue metachromasia, mature basophil-associated antigen expression, and characteristic granules under electron microscopy. The molecular link between t(16;21)/FUS-ERG and basophilic differentiation remains unclear.

Keyphrases

rare case
acute myeloid leukemia
liver failure
bone marrow
electron microscopy
respiratory failure
copy number
genome wide
aortic dissection
poor prognosis
drug induced
genome wide identification
intensive care unit
gene expression
single molecule
long non coding rna
binding protein