Management of critical-sized bone defects in the treatment of fracture-related infection: a systematic review and pooled analysis.

Hans BezstarostiW J MetsemakersE M M van LieshoutL W VoskampK KortramM A McNallyL C MaraisM H J Verhofstad

Published in: Archives of orthopaedic and trauma surgery (2020)

Results should be interpreted with caution due to the retrospective and observational design of most studies, the lack of clear classification systems, incomplete data reports, potential underreporting of adverse outcomes, and heterogeneity in patient series. A consensus on classification, treatment protocols, and outcome is needed to improve reliability of future studies.

Keyphrases

machine learning
deep learning
cross sectional
electronic health record
big data
case report
combination therapy
bone mineral density
risk assessment
current status
postmenopausal women
replacement therapy
bone loss