Tubulointerstitial nephritis antigen-like 1 from cancer-associated fibroblasts contribute to the progression of diffuse-type gastric cancers through the interaction with integrin β1.

Dagyeong LeeIn-Hye HamHye Jeong OhDong Min LeeJung Hwan YoonSang-Yong SonTae-Min KimJae-Young KimSang-Uk HanHoon Hur

Published in: Journal of translational medicine (2024)

These results indicate that TINAGL1 secreted by CAFs induces phosphorylation of FAK in DGC cells and promotes tumor progression. Thus, targeting TINAGL1 in CAFs can be a novel therapeutic strategy for DGC.

Keyphrases

induced apoptosis
cell cycle arrest
poor prognosis
cell migration
low grade
cancer therapy
endoplasmic reticulum stress
oxidative stress
protein kinase
cell proliferation
drug delivery
young adults