Effects of Kamishoyosan, a Traditional Japanese Medicine, on Menopausal Symptoms: A Randomized, Placebo-Controlled, Double-Blind Clinical Trial.
Kiyoshi TakamatsuMariko OgawaTsuyoshi HiguchiTakashi TakedaKunihiko HayashiHideki MizunumaPublished in: Evidence-based complementary and alternative medicine : eCAM (2020)
This first placebo-controlled double-blind randomized trial with kamishoyosan demonstrated that it was safe and had some effects on climacteric symptoms, but not significant compared with placebo. Some problems, such as placebo effects, in the study of Kampo therapy for menopausal symptoms, were revealed. This trial is registered with the trial registration number. UMIN 000006042.