CD105 (Endoglin) as negative prognostic factor in AML.
Joseph KauerKarolin SchwartzClaudia TandlerClemens HinterleitnerMalte RoerdenGundram JungHelmut R SalihJonas S HeitmannMelanie MärklinPublished in: Scientific reports (2019)
While several genetic and morphological markers are established and serve to guide therapy of acute myeloid leukaemia (AML), there is still profound need to identify additional markers to better stratify patients. CD105 (Endoglin) is a type I transmembrane protein reported to induce activation and proliferation of endothelial cells. In addition, CD105 is expressed in haematological malignancies and the vessels of solid tumours. Here, CD105 associates with unfavourable disease course, but so far no data are available on the prognostic relevance of CD105 in haematological malignancies. We here generated a novel CD105 antibody for analysis of expression and prognostic relevance of CD105 in a cohort of 62 AML patients. Flow cytometric analysis revealed substantial expression in the various AML FAB types, with FAB M3 type displaying significantly lower surface levels. Next we established a cut-off specific fluorescence level of 5.22 using receiver-operating characteristics, which allowed to group patients in cases with CD105lo and CD105hi surface expression and revealed that high CD105 expression correlated significantly with poor overall and progression free survival. In conclusion, we here identify CD105 expression as a novel prognostic marker in AML, which may serve to optimize follow up and treatment decisions for AML patients.
Keyphrases
- end stage renal disease
- prognostic factors
- acute myeloid leukemia
- poor prognosis
- ejection fraction
- newly diagnosed
- chronic kidney disease
- endothelial cells
- nk cells
- peritoneal dialysis
- free survival
- immune response
- binding protein
- mesenchymal stem cells
- single molecule
- dendritic cells
- single cell
- liver failure
- cell therapy
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- respiratory failure
- mechanical ventilation