Placental 13C-DHA metabolism and relationship with maternal BMI, glycemia and birthweight.
Oliver C WatkinsPreben SelvamReshma Appukuttan PillaiVictoria K B Cracknell-HazraHannah E J YongNeha SharmaAmaury Cazenave-GassiotAnne K BendtKeith M GodfreyRohan M LewisMarkus R WenkShiao-Yng ChanPublished in: Molecular medicine (Cambridge, Mass.) (2021)
Maternal BMI and glycemia increased the production of different placental DHA lipids implying impact on different metabolic pathways. Glucose-induced elevation in placental DHA metabolism is moderated with higher maternal BMI. In turn, findings of associations between many DHA lipids with birthweight suggest that BMI and glycemia promote fetal growth partly through changes in placental DHA metabolism.