Low dose of valproate improves motor function after traumatic brain injury.

Yu-Ting TaiWen-Yuan LeeFei-Peng LeeTien-Jen LinChia-Lin ShihJia-Yi WangWen-Ta ChiuKuo-Sheng Hung

Published in: BioMed research international (2014)

The results indicated that treating adult rats with VPA after TBIs significantly decreased the contusion volume and recovery of contusion-related skilled forelimb reaching deficits. Applying VPA also increased histone acetylation, p-ERK, and p-CREB expression in the brain. Furthermore, applying VPA reduced inflammation, glial fibrillary acidic protein activation, and apoptosis. Conclusion. This study found that 30 mg/kg of VPA assists in treating TBIs in rat models.

Keyphrases

oxidative stress
low dose
spinal cord
poor prognosis
signaling pathway
binding protein
traumatic brain injury
dna methylation
high dose
endoplasmic reticulum stress
cell death
resting state
spinal cord injury
young adults
long non coding rna
pi k akt
protein protein
acute care
drug induced