DHEA Attenuates Microglial Activation via Induction of JMJD3 in Experimental Subarachnoid Haemorrhage.

Tao TaoGuang-Jie LiuXuan ShiYan ZhouYue LuYong-Yue GaoXiang-Sheng ZhangHan WangLing-Yun WuChun-Lei ChenZong ZhuangWei LiChun-Hua Hang

Published in: Journal of neuroinflammation (2019)

DHEA has a neuroprotective effect after SAH. Moreover, DHEA increases microglial JMJD3 expression to regulate proinflammatory/anti-inflammatory microglial activation after haemoglobin exposure, thereby suppressing inflammation.

Keyphrases

inflammatory response
lipopolysaccharide induced
lps induced
neuropathic pain
anti inflammatory
poor prognosis
oxidative stress
signaling pathway
spinal cord
spinal cord injury
binding protein
cerebral ischemia
long non coding rna
subarachnoid hemorrhage
blood brain barrier