Antitubercular and cytotoxic polyoxygenated cyclohexane derivatives from Uvaria grandiflora.
Allan Patrick G MacabeoAngeli Izza G FloresRey Arturo T FernandezSimon BuddeChristian FaderlHans-Martin DahseScott G FranzblauPublished in: Natural product research (2020)
Chromatographic purification of the DCM sub-extract of Uvaria grandiflora led to the isolation and characterization of a new polyoxygenated cyclohexane derivative, grandifloranol (1), together with five known compounds. Among the compounds isolated, zeylenone (3) showed moderate antitubercular activity against Mycobacterium tuberculosis H37Rv with MIC90 value of 51.2 μM and antiproliferative or cytotoxic activity against human myeloid leukaemia (K-562) and HeLa cells with IC50 values of 2.3 and 18.3 μM, respectively.
Keyphrases
- mycobacterium tuberculosis
- cell cycle arrest
- induced apoptosis
- endothelial cells
- pulmonary tuberculosis
- oxidative stress
- dendritic cells
- bone marrow
- acute myeloid leukemia
- high intensity
- signaling pathway
- pi k akt
- immune response
- endoplasmic reticulum stress
- induced pluripotent stem cells
- high resolution
- pluripotent stem cells
- mass spectrometry
- structure activity relationship