Large-scale map of RNA binding protein interactomes across the mRNA life-cycle.
Lena Annika StreetKatherine RothamelKristopher BrannanWenhao JinBenjamin BokorKevin DongKevin RhineAssael MadrigalNorah Al-AzzamJenny Kim KimYanzhe MaAhmed AbdouErica WolinElla Doron-MandelJoshua AhdoutMayuresh MujumdarMarko JovanovicGene W YeoPublished in: bioRxiv : the preprint server for biology (2023)
An RBP-centric RNA-aware PPI network focuses on the mRNA life-cycle in human cellsPrey-prey correlation analysis assigns prey proteins to life-cycle stages, of which 536 proteins (half of the network) interact with multiple stepsERH is highly connected to multiple RNPs to affect nuclear speckle organization and mRNA exportSplicing factor SNRNP200 interacts with stress granule proteins and has distinct RNA occupancy in the cytoplasm.