Shared and Distinctive Transcriptomic and Proteomic Pathways in Adult and Juvenile Dermatomyositis.
James M WardMythri AmbatipudiTerrance P O'HanlonMichael A SmithMelissa de Los ReyesAdam SchiffenbauerSaifur RahmanKamelia ZerroukiFrederick W MillerMiguel A SanjuanJian-Liang LiKerry A CaseyLisa G RiderPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2023)
The combination of proteomics and transcript expression by multi-enrichment analysis broadened the identification of up- and down-regulated pathways among active DM and JDM patients. These pathways, particularly those which feed into PI3K/AKT and MAPK signaling and neutrophil degranulation, may be potential therapeutic targets.
Keyphrases
- pi k akt
- signaling pathway
- end stage renal disease
- cell proliferation
- ejection fraction
- chronic kidney disease
- cell cycle arrest
- newly diagnosed
- transcription factor
- poor prognosis
- single cell
- rna seq
- label free
- oxidative stress
- interstitial lung disease
- long non coding rna
- adipose tissue
- metabolic syndrome
- binding protein
- weight loss