Differential Expression of Long Noncoding RNA HOTAIR in Intestinal Metaplasia and Gastric Cancer.

Vytenis PetkeviciusCosima ThonRuta SteponaitieneJurgita SkiecevicieneDainius JanciauskasDoerthe JechorekPeter MalfertheinerJuozas KupcinskasAlexander Link

Published in: Clinical and translational gastroenterology (2022)

HOTAIR expression was associated with GC and preneoplastic changes of stomach mucosa. Although HOTAIR expression was strongly linked to IM, HOTAIR expression was only associated with worse prognosis in Lauren diffuse and not intestinal type of GC. Further studies are needed to evaluate the value of HOTAIR as diagnostic and predictive biomarker in IM and translational therapeutic relevance of HOTAIR in diffuse-type GC.

Keyphrases

poor prognosis
long noncoding rna
binding protein
low grade
high resolution
high grade