Recent advances in lung cancer research: unravelling the future of treatment.
Lorenzo SpaggiariMonica CasiraghiClarissa UslenghiSebastiano MaiorcaLorenzo SpaggiariPublished in: Updates in surgery (2024)
Lung cancer, a multifaceted disease, demands tailored therapeutic approaches due to its diverse subtypes and stages. This comprehensive review explores the intricate landscape of lung cancer research, delving into recent breakthroughs and their implications for diagnosis, therapy, and prevention. Genomic profiling and biomarker identification have ushered in the era of personalised medicine, enabling targeted therapies that minimise harm to healthy tissues while effectively combating cancer cells. The relationship between pulmonary tuberculosis and lung cancer is examined, shedding light on potential mechanisms linking these two conditions. Early detection methods, notably low-dose computed tomography scans, have significantly improved patient outcomes, emphasising the importance of timely interventions. There has been a growing interest in segmentectomy as a surgical intervention for early-stage lung cancer in recent years. Immunotherapy has emerged as a transformative approach, harnessing the body's immune system to recognise and eliminate cancer cells. Combining immunotherapy with traditional treatments, such as chemotherapy and targeted therapies, has shown enhanced efficacy, addressing the disease's heterogeneity and overcoming drug resistance. Precision medicine, guided by genomic profiling, has enabled the development of targeted therapies like tyrosine kinase inhibitors, offering personalised treatments tailored to individual patients. Challenges such as drug resistance and limited accessibility to advanced therapies persist, emphasising the need for collaborative efforts and innovative technologies like artificial intelligence. Despite challenges, ongoing interdisciplinary collaborations and technological advancements offer hope for a future where lung cancer is treatable and preventable, reducing the burden on patients and healthcare systems worldwide.
Keyphrases
- computed tomography
- end stage renal disease
- artificial intelligence
- early stage
- low dose
- healthcare
- ejection fraction
- pulmonary tuberculosis
- single cell
- newly diagnosed
- chronic kidney disease
- randomized controlled trial
- big data
- peritoneal dialysis
- gene expression
- stem cells
- squamous cell carcinoma
- quality improvement
- risk assessment
- high dose
- current status
- emergency department
- radiation therapy
- copy number
- physical activity
- dna methylation
- bone marrow
- pet ct