Treatment of inflammatory bowel disease via green tea polyphenols: possible application and protective approaches.
Sajid Ur RahmanYu LiYingying HuangLei ZhuShibin FengJinjie WuXichun WangPublished in: Inflammopharmacology (2018)
Inflammatory bowel disease (IBD) is a collection of inflammatory conditions of colon and small intestine which affect millions of individuals worldwide and the prevalence amount is on the rise. The organ failure as well as loss of tissue function is because of the inflammatory reaction which is the major contributor of tissue healing leading to lifelong debilitation. To stop the tough consequences of inflammation every patient pursues alternative therapy to relieve symptoms. Green tea polyphenols (GTPs) play significant roles in down regulating signaling pathways because GTPs exert effective antioxidant properties and regulate Toll-like receptor 4 (TLR4) expression via certain receptor, inhibited endotoxin-mediated tumor necrosis factor alpha (TNF-α) production by blocking transcription nuclear factor-kappa B (NF-kB) activation and upstream of mediated I kappa B kinase complex pathway activities, as well as intrusion with the flow of cytokines and synthesis of cyclooxygenase-2 (COX-2). This article highlights the green approach regarding the defensive effects of GTP review-related studies concerning the contrary effects and the key therapeutic targets application of GTPs in biomedical field to treat inflammatory bowel disease (IBD) and its complications. .
Keyphrases
- nuclear factor
- toll like receptor
- oxidative stress
- ulcerative colitis
- inflammatory response
- rheumatoid arthritis
- immune response
- signaling pathway
- risk factors
- poor prognosis
- case report
- binding protein
- induced apoptosis
- transcription factor
- stem cells
- long non coding rna
- epithelial mesenchymal transition
- pi k akt
- replacement therapy
- depressive symptoms
- cell proliferation
- combination therapy
- bone marrow
- physical activity
- case control