Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells.

Jing WangShuqin LiuXinxiu MengXuan ZhaoTianhui WangZhiyong Lei Helge Immo Lehmann Guoping Li Pilar Alcaide Yihua Bei Junjie Xiao

Published in: Circulation research (2024)

Our results demonstrate that exercise training protects against doxorubicin-induced cardiotoxicity by upregulating Fc gamma receptor IIB expression in B cells, which plays an important anti-inflammatory role and participates in the protective effect of exercise against doxorubicin-induced cardiotoxicity.

Keyphrases

high glucose
diabetic rats
drug delivery
physical activity
high intensity
drug induced
poor prognosis
endothelial cells
oxidative stress
stress induced