Comparative effectiveness of daptomycin versus vancomycin among patients with methicillin-resistant Staphylococcus aureus (MRSA) bloodstream infections: A systematic literature review and meta-analysis.
Adamu YauMireia Puig-AsensioBashir DaboMarin L SchweizerPublished in: PloS one (2024)
Compared with vancomycin, an early switch from vancomycin to daptomycin was significantly associated with lower odds of mortality. In contrast, switching to daptomycin at any time only showed a trend towards reduced mortality, with a non-significant association. Therefore, the efficacy of early daptomycin use over vancomycin against mortality among MRSA BSIs patients may add evidence to the existing literature in support of switching to daptomycin early over remaining on vancomycin. More randomized and prospective studies are needed to assess this association.
Keyphrases
- methicillin resistant staphylococcus aureus
- staphylococcus aureus
- cardiovascular events
- end stage renal disease
- risk factors
- systematic review
- newly diagnosed
- ejection fraction
- magnetic resonance
- open label
- randomized controlled trial
- clinical trial
- prognostic factors
- cardiovascular disease
- coronary artery disease
- type diabetes
- phase iii
- patient reported outcomes
- contrast enhanced