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Ru(OAc) 3 -Catalyzed Regioselective Difunctionalization of Alkynes: Access to ( E )-2-Bromo-1-alkenyl Sulfonates.

Lu ChenYa LiXiaoyan BaiDian DongMeiwei PanLing HuangRunqin HuangXiaotong LongYibiao Li
Published in: Organic letters (2023)
A new approach is proposed for the divergent and regioselective synthesis of ( E )-2-bromo-1-phenylvinyl trifluoromethanesulfonates through alkyne difunctionalization by employing a compatible system of abundantly available alkynes, N -bromosuccinimide (NBS), and trimethylsilyl trifluoromethanesulfonate (TMSOTf) catalyzed by ruthenium(III) acetate [Ru(OAc) 3 ]. It is a novel method for the preparation of vinyl triflate and it offers a fundamental basis for the development of advanced functional compounds, including drugs and organic functional materials. Unlike previously reported methods, the proposed protocol can tolerate a broad range of functional groups. Alkynes derived from bioactive molecules, such as l(-)-borneol, demonstrate the potential value of this new reaction in organic synthesis.
Keyphrases
  • room temperature
  • randomized controlled trial
  • mass spectrometry
  • water soluble