Unlocking the Pancreatic Cancer Puzzle: Using Intermediate Cells to Target Treatment.
Erika Y FaraoniFlorencia McAllisterPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
KRT17-high intermediate cell population with elevated CXCL8 expression informed elevated myeloid infiltration status in tumors and associated with pro-tumorigenic signatures in peripheral granulocytes from pancreatic cancer patients. Further, CXCL8 plasma levels were found to resemble KRT17+/CXCL8+ abundance in tumors, in which higher levels predicted worse patient outcomes.
Keyphrases
- induced apoptosis
- poor prognosis
- single cell
- cell cycle arrest
- bone marrow
- dendritic cells
- cell therapy
- acute myeloid leukemia
- anti inflammatory
- genome wide
- endoplasmic reticulum stress
- signaling pathway
- long non coding rna
- binding protein
- cell proliferation
- combination therapy
- antibiotic resistance genes
- mesenchymal stem cells