Differential effects of omega-3 PUFAS on tumor progression at early and advanced stages in TRAMP mice.

Gustavo M AmaroAlana D T da SilvaGuilherme H TamarindoCelina de A LamasSebastião Roberto Taboga Valéria Helena Alves Cagnon Quitete Rejane Maira Góes

Published in: The Prostate (2022)

(n-3) PUFAs had a protective effect at early stages of PCa, delaying tumor progression in TRAMP mice, in parallel with reductions in cell proliferation, AR, and GR and maintenance of the stromal compartment of the gland. However, (n-3) PUFAs did not prevent the development of primary tumors for the T20 group, reinforcing the need for further investigation at advanced stages of disease.

Keyphrases

cell proliferation
poor prognosis
high fat diet induced
bone marrow
type diabetes
metabolic syndrome
long non coding rna
skeletal muscle