CD98hc has a pivotal role in maintaining the immuno-barrier integrity of basal layer cells in esophageal epithelium.

Hao YeXiang LiJing LinPeng YangMin Su

Published in: Cancer cell international (2022)

Our study revealed that CD98hc was a marker of cells originated from basal cell in esophagus, ectopic expression of CD98hc in hyperplastic/dysplastic cells by chronic inflammation stimulation crippled the linkage between basal cell and basement membrane, sabotaged the integrity of the barrier in between lamina propria and epithelium, subsequentially initiate carcinogenesis.

Keyphrases

induced apoptosis
cell cycle arrest
single cell
poor prognosis
cell therapy
stem cells
cell death
gene expression
nk cells
long non coding rna
mesenchymal stem cells
binding protein
dna methylation
hiv infected
pi k akt