Sputum microRNA-screening reveals Prostaglandin EP3 receptor as selective target in allergen-specific immunotherapy.
Constanze A JakwerthAdam M ChakerFerdinand GuerthMadlen OelsnerLisa PechtoldLynn S Zur BonsenJulia T UllmannSusanne Krauss-EtschmannAnna ErbJosephine KauMirjam PlaschkeMarlene WinklerAlexandra KurzAntonia KlossJulia Esser-von BierenCarsten B Schmidt-WeberUlrich M ZisslerPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2021)
While profiling the sputum of allergic patients for novel miR expression patterns, we uncovered an association between miR-3935 and its predicted target gene, the prostaglandin E3 receptor, which might mediate AIT effects through suppression of the PGE2 -PTGER3 axis.
Keyphrases
- cell proliferation
- long non coding rna
- end stage renal disease
- cystic fibrosis
- mycobacterium tuberculosis
- poor prognosis
- long noncoding rna
- newly diagnosed
- chronic kidney disease
- ejection fraction
- pulmonary tuberculosis
- peritoneal dialysis
- binding protein
- prognostic factors
- copy number
- gene expression
- patient reported outcomes
- patient reported