A systematic review and meta-analysis of enrollment into ARDS and sepsis trials published between 2009 and 2019 in major journals.
Dustin C KrutsingerKuldeep N YadavMichael O HarhayKarsten BartelsKatherine R CourtrightPublished in: Critical care (London, England) (2021)
In this systematic review and meta-analysis, recent ARDS/ALI and sepsis clinical trials had an overall enrollment rate of less than 1 participant per site per month. Novel approaches to improve critical care trial enrollment efficiency are needed to facilitate the translation of best evidence into practice.
Keyphrases
- clinical trial
- health insurance
- acute respiratory distress syndrome
- intensive care unit
- septic shock
- mechanical ventilation
- acute kidney injury
- extracorporeal membrane oxygenation
- affordable care act
- phase ii
- phase iii
- primary care
- healthcare
- study protocol
- meta analyses
- randomized controlled trial
- systematic review
- quality improvement