The response to neoadjuvant chemoradiotherapy with 5-fluorouracil in locally advanced rectal cancer patients: a predictive proteomic signature.
Anaïs ChauvinChang-Shu WangSameh GehaPerrine Garde-GrangerAlex-Ane MathieuVincent LacasseFrançois-Michel BoisvertPublished in: Clinical proteomics (2018)
From these retrospective study, we implemented a protein extraction protocol from FFPE biopsy to highlight protein differences between different response groups to RCTN with 5-FU in patients with locally advanced non-metastatic rectal cancer. These results will pave the way for a larger cohort for better sensitivity and specificity of the signature to guide decisions in the choice of treatment.
Keyphrases
- locally advanced
- rectal cancer
- neoadjuvant chemotherapy
- squamous cell carcinoma
- phase ii study
- radiation therapy
- end stage renal disease
- small cell lung cancer
- protein protein
- randomized controlled trial
- newly diagnosed
- chronic kidney disease
- ejection fraction
- amino acid
- peritoneal dialysis
- clinical trial
- prognostic factors
- binding protein
- small molecule
- combination therapy
- patient reported outcomes
- smoking cessation
- replacement therapy