Plastics impact our daily lives. Unfortunately, it is the disuse and disposal of these items that may affect us the greatest. Plastic micro- and nanosized particles, likely from bulk degradation, have been identified in air pollution and water sources. Recently, plastic particles have also been identified in consumable products. The purpose of this review is to identify the likely routes of human exposure, the toxicological outcomes and concerns currently reported, and to provide some considerations for future assessments.