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Phase I study of primary treatment with 5-FU, oxaliplatin, irinotecan, levofolinate, and panitumumab combination chemotherapy in patients with advanced/recurrent colorectal cancer involving the wild-type RAS gene: the JACCRO CC-14 study.

Hironaga SatakeAkihito TsujiMasato NakamuraMasaaki OgawaTakeshi KotakeYukimasa HatachiHisateru YasuiAkinori TakaganeYoshihiro OkitaKumi NakamuraToshihide OnikuboMasahiro TakeuchiMasashi Fujii
Published in: International journal of clinical oncology (2018)
The FOLFOXIRI + panitumumab chemotherapy regimen was well tolerated by our patients with mCRC and showed promising anti-tumor activity. The recommended phase II dose was determined to be the same as the standard doses of this regimen used worldwide.
Keyphrases
  • wild type
  • phase ii
  • clinical trial
  • open label
  • squamous cell carcinoma
  • gene expression
  • randomized controlled trial
  • copy number
  • radiation therapy
  • genome wide
  • double blind