Diffuse large B-cell lymphoma with uncommon cardiac invasion.
Yunis DaralammouriHamza HamayelYahya IsmailSajed MajadlaRazan OdehPublished in: SAGE open medical case reports (2022)
Diffuse large B-cell lymphoma is the most common histologic subtype of non-Hodgkin lymphoma. Secondary involvement of the heart is seen late in advanced cases, it is uncommon for diffuse large B-cell lymphoma to present as intracardiac mass. A 26-year-old female patient presented with progressive shortness of breath, facial swelling, and lower limb edema. Imaging investigations by echocardiography and computed tomography showed a large right atrial mass that was obstructing the tricuspid valve. Open biopsy was taken, histopathology showed diffuse large B-cell lymphoma. She received six cycles R-CHOP chemotherapy (rituximab, cyclophosphamide, epirubicin, vincristine, and prednisone) with complete resolution of the mass. Diffuse large B-cell lymphoma can present with atypical and uncommon sites such as the heart as the first presentation. Early diagnosis and appropriate management is crucial given the poor outcome with late presentation. A high index of suspicion and the proper investigations is recommended to allow for early intervention and favorable outcomes as what happened with the case under discussion.
Keyphrases
- diffuse large b cell lymphoma
- epstein barr virus
- computed tomography
- lower limb
- heart failure
- case report
- left ventricular
- mitral valve
- atrial fibrillation
- randomized controlled trial
- high resolution
- multiple sclerosis
- magnetic resonance imaging
- low dose
- high dose
- aortic stenosis
- locally advanced
- left atrial
- cell migration
- contrast enhanced
- rectal cancer
- chemotherapy induced